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Determination of acute tolerance to antinociceptive effect (mouse WWTW assay) of 4. Mice were treated with 10 mg/kg 4 (closed squares) or saline (open circles), and the time course of the antinociceptive response was determined. At t = 90 min (indicated by dashed vertical line) both groups of mice were injected with 10 mg/kg 4 and antinociceptive response was again examined.
