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. 2014 Feb 24;13(4):2109–2119. doi: 10.1021/pr4012602

Figure 1.

Figure 1

Generation of an MDM reference spectral library. (A) The experimental approach for generation of an MDM reference spectral library used two distinct set of samples: total nuclear proteins and soluble nuclear proteins. (B) ProteinPilot analyzed nearly 1 million spectra to produce an MDM reference spectral library containing 3030 protein groups (3743 proteins total) with greater than 99% confidence and all these proteins passed global FDR from fit analysis (C). The 3030 protein groups were analyzed by PANTHER (D) for protein class and revealed enrichment for nucleic acid binding proteins and for transcription factors.