Figure 5.

A proposed model for nucleic acid binding and regulatory protein dysregulation in HIV-1 infection of MDM. Upon HIV-1 infection and replication (A), cell-signaling cascades are activated resulting in differential activation of transcription regulator proteins and subsequent alterations in biomolecule expression impacting the transcriptome and the proteome (B). We have provided evidence for the reprogramming of host protein expression in response to HIV-1 infection at the level of nucleic acid binding and regulatory proteins involved in transcription (C) and RNA processing (D). Proteins predicted to be HIV-1 dependency factors are indicated with an asterisk (*).