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. Author manuscript; available in PMC: 2015 Mar 15.
Published in final edited form as: J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Feb 14;0:126–131. doi: 10.1016/j.jchromb.2014.02.001

Table 2.

Summary of the previous studies of 2-HPMA in the urine of smokers and nonsmokers. Qlow and Qhigh denote quality control pooled urine samples to which 40 and 400 ng/mL 2-HPMA were added, respectively. Dashes are used where data were not reported.

Schettgen et al. (2008)
Aachen, Germany		 Eckert et al. (2011)
Erlangen, Germany		 Alwis et al. (2012)
Atlanta, GA, U.S.A.
Accuracy, %
(Range)		 Qhigh: 114
(104–129)		 Qlow: 70
(64–78)		 —
(95–106)		 105
(101–109)
Precision (CV, %)
Intraday / Interday		 Qhigh:
7.3 / 13.4		 Qlow:
4.9 / 22.2		 < 10 / < 10 — / (6.6–8.5)
LOD, pmol/mL 23 23 5.9
Smokers Nonsmokers Smokers Nonsmokers Smokers Nonsmokers
Subjects, n 14 14 40 54 347 1,203
Median 2-HPMA,
pmol/mg creatinine
(Range)		 170
(< 23–934)		 21
(< 23–333)		 209
(14–1235)		 55
(14–122)		 — —
Mean 2-HPMA,
pmol/mL
(± S.D.)		 — — — — 837
(± 1063)		 367
(± 534)