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. Author manuscript; available in PMC: 2014 Apr 21.
Published in final edited form as: Alcohol Clin Exp Res. 2011 Jul 25;35(12):2139–2151. doi: 10.1111/j.1530-0277.2011.01569.x

Figure 1.

Figure 1

Effects of chronic ethanol feeding and NAC treatment on steatohepatitis. Adult male Sprague-Dawley rats were fed for 130 days with chow (A, F, K), control TEN (B, G, L), control TEN supplemented with NAC (C, H, M), ethanol TEN (37% by caloric content; D, I, N), or ethanol TEN supplemented with NAC (E, J, O). Paraffin-embedded histological sections (5 µm thick) of liver were stained with H&E and photographed at 40× (A–E), 160× (F–J), and 400× (K–O) magnifications. Note reduced inflammation and shift from microvesicular steatosis to macrovesicular steatosis associated with NAC treatments, but persistence of hepatic chord architecture disarray in the control liquid + ethanol livers despite NAC treatment.