Figure 3. The RING domain of March8 is critical for induction of embryonic defects.

The classification of morphological defects at 26 hpf after march8 mRNA injection is shown at the left. Quantification shows that defects were induced in a dose-dependent manner by WT, but very weakly by W109A mutant march8 mRNA. Number of embryos is listed on top of bars. UI, uninjected; GFP, embryos injected with 50 pg GFP mRNA.