Table 1. Characteristics of patients with TSCC and BOTSCC and their tumours.

	HPV-positive tumours		HPV-negative tumours		All patients/tumours		p-value*
Patient Characteristics	207		71		278
	N	%	N	%	N	%
Age (years)
Mean	60		64		61		<0.001
Median	60		62		61
Range	30–90		44–100		30–100
Diagnosis
TSCC	144	69.6%	51	71.8%	195	70.1%	0.72
BOTSCC	63	30.4%	20	28.2%	83	29.9%
Sex
Male	156	75.4%	54	76.1%	210	75.5%	0.84
Female	51	24.6%	17	23.9%	68	24.5%
Tumor size
T1	52	25.1%	12	16.9%	64	23.0%	0.018
T2	74	35.7%	16	22.5%	90	32.4%
T3	36	17.4%	21	29.6%	57	20.5%
T4	45	21.7%	22	31.0%	67	24.1%
Nodal disease
N0	27	13.0%	29	40.8%	56	20.1%	<0.001
N1	50	24.2%	9	12.7%	59	21.2%
N2a	36	17.4%	5	7.0%	41	14.7%
N2b	63	30.4%	11	15.5%	74	26.6%
N2c	22	10.6%	10	14.1%	32	11.5%
N3	9	4.3%	7	9.9%	16	5.8%
NX	0	0.0%	0	0.0%	0	0.0%
Distant metastasis
M0	200	96.6%	69	97.2%	269	96.8%	0.84
M1	5	2.4%	1	1.4%	6	2.2%
MX	2	1.0%	1	1.4%	3	1.1%
Stage
I	1	0.5%	9	12.7%	10	3.6%	<0.001
II	12	5.8%	5	7.0%	17	6.1%
III	53	25.6%	17	23.9%	70	25.2%
IVa	126	60.9%	31	43.7%	157	56.5%
IVb	10	4.8%	9	12.7%	19	6.8%
Ivc	5	2.4%	0	0.0%	5	1.8%
Treatment
Curative	199	96.1%	59	83.1%	258	92.8%	<0.001
Palliative	8	3.9%	12	16.9%	20	7.2%
Smoking
Never	67	32.4%	5	7.0%	72	25.9%	<0.001
Former (>15years ago)	38	18.4%	3	4.2%	41	14.7%
Former (<15years ago)	38	18.4%	4	5.6%	42	15.1%
Current at diagnosis	58	28.0%	50	70.4%	108	38.8%

*p-value for comparison of HPV-positive vs. HPV-negative tumours/patients.