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. 2014 Apr 21;9(4):e95931. doi: 10.1371/journal.pone.0095931

Figure 2. Effect of BE-IS on carrageenan-induced right hind paw edema in rats.

Figure 2

Rats were divided randomly into five groups: Control group (0.5% CMC-Na), Ibuprofen group (200 mg/kg) and BE-IS groups (100, 200, and 400 mg/kg). Paw edema was induced by subplantar injection of 0.1 ml of 1% freshly prepared carrageenan suspension in normal saline into the right hind paw of each rat. Paw size was measured as the paw circumference immediately before and once an hour for 6 h after carrageenan injection. Values are expressed as mean ± S.E., n = 10, *P<0.05, ** <0.01 as compared to the control group.