Figure 2.

AAV effectively transduced periodontal tissue and Rgs10 knockdown efficiently protected mice from bone loss in W50-stimulated periodontitis. (A) Mouse maxillary molars showing AAV injection sites (black arrows). Fluorescence microscope image reveals eGFP expression after local injection with AAV-sh-Rgs10 compared with normal mouse tissues that did not receive AAV treatment. (B) Representative figures of periodontal bone resorption and root exposure from different groups. (C) There was no significant difference in bone loss between the normal group and the AAV-sh-Rgs10 treatment group (P>0.05). In addition, the AAV-sh-Rgs10 treatment group had significantly less bone loss compared with the AAV-sh-luc-YFP treatment group (P<0.01) (N=9, n=3 per group, repeated 3 times). N.S: no significant; **P<0.01.