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. 2014 Apr 21;9(4):e95762. doi: 10.1371/journal.pone.0095762

Figure 3. Motor deficit.

Figure 3

Motor deficit when C21 is given either pre-stroke (A) or post-stroke (B). For pre-treatment, the effect of vehicle (saline) control (n = 9), AT2R agonist C21 at 5 ng/kg/min (n = 7), 10 ng/kg/min (n = 11) and 50 ng/kg/min (n = 11), AT2R antagonist PD123319 alone (36 ng/kg/min; n = 10) and in combination with C21 (50 ng/kg/min; n = 8) on percentage errors made on the ledged beam following stroke. For post-stroke treatment, the effect of vehicle (n = 12), AT2R agonist C21 (144 µg/kg/dose; n = 11), AT2R antagonist PD123319 alone (103 µg/kg/dose; n = 12) and in combination with C21 (144 µg/kg/dose; n = 6) on percentage errors made on the ledged beam following stroke. Ledged beam test was performed pre-stroke (P) and at 1 (1 day) and 3 (3 day) post stroke. Mean data+SEM; *P<0.01 vs. vehicle pre-stroke (1-way RM ANOVA); #P<0.01 vs. corresponding time in vehicle-treated group (2-way RM ANOVA).