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. 2014 Apr 21;9(4):e95762. doi: 10.1371/journal.pone.0095762

Figure 4. Neuronal survival.

Figure 4

Neuronal survival when C21 is given either pre-stroke (A) or post-stroke (B). For pre-treatment, the effect of vehicle (saline; n = 7); AT2R agonist C21 alone (50 ng/kg/min; n = 8) and in combination with AT2R antagonist PD123319 (36 ng/kg/min; n = 6) on neuronal survival at 72 hours post stroke. For post-stroke treatment, the effect of vehicle (n = 8), AT2R agonist C21 (144 µg/kg/dose; n = 8), AT2R antagonist PD123319 (103 µg/kg/dose; n = 8) in combination with C21 (144 µg/kg/dose; n = 6) on neuronal survival at 72 hours post stroke. Data expressed as the number of NeuN-immunopositive cells in infarcted (open columns) and non-infarcted (filled columns) cortical regions on the ipsilateral hemisphere. Mean data±SEM. *P<0.05 vs. corresponding region in vehicle group; #P<0.05 vs. non-infarcted region within same animal (1-way ANOVA).