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One additional case of primary adenocarcinoma of the urinary bladder (pT3) is highly infiltrative with some mucinous features on H&E (A). p16 shows strong nuclear and cytoplasmic reactivity in a majority of cells, but there is some variability in the staining (B). No reactivity is seen with either p53 (C) or HPV (D) immunostains in this case. Controls for HPV immunohistochemistry (E) and in situ hybridization (F) are demonstrated here.
