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| Antibody or ISH method used | p16 | p53 | HPV IHC* | HPV-ISH† |
| Staining extent ‡ | ||||
| 0 | 12 | 15 | 36 | 36 |
| 1+ | 11 | 0 | 0 | 0 |
| 2+ | 5 | 6 | 0 | 0 |
| 3+ | 8 | 15 | 0 | 0 |
| Any reactivity by tumor stage | ||||
| pT1 | 7 | 10 | 0 | 0 |
| pT2 | 6 | 5 | 0 | 0 |
| pT3 | 8 | 5 | 0 | 0 |
| pT4 | 3 | 1 | 0 | 0 |
*IHC = immunohistochemistry.
ISH = in situ hybridization.
Staining extent is defined within the “Methods” section of the text.
