Table 2. Top pathways with affected genes altered by Cebpa knockdown^*.

Pathway	−logP	R	Genes
Production of NOand reactive O2 inmacrophages	4.74	0.076	MAP3K11,MAP3K6,MPO,IKBKE,IFNGR1,TLR4,NFKBIA, RHOB, RND3,CYBA,RHOU,S100A8,TNF,MAP3K3,SIRPA,PRKCB
Interleukin-10signaling	3.43	0.103	NFKBIA,FCGR2A,BLVRB,IL1B,IKBKE,LBP, FCGR2B,TNF
LPS/IL-1mediatedinhibition of RXRfunction	3.20	0.063	ALDH4A1,MGST1,GSTM5,CHST12,PAPSS2,TLR4,HS6ST1,MGST2, IL1B, ALAS1,ALDH3B1,LBP,CHST13,TNF,ACSL1
Inhibitor of NOsynthase (iNOS)signaling	3.04	0.113	TLR4,NFKBIA,IKBKE,IFNGR1,LBP,IRAK3
Aryl hydrocarbonreceptor signaling	2.99	0.068	TGM2,ALDH4A1,MGST1,MGST2,GSTM5,CDKN1A,IL1B,ALDH3B1, CCND1,TNF,NFE2L2
Interleukin-8signaling	2.97	0.064	VCAM1,NRAS,ANGPT1,MPO,IKBKE,IRAK3,CCND1, PLD1,CSTB, RND3,RHOB,RHOU,PRKCB
Hepatocytegrowth factorsignaling	2.96	0.086	ETS1,NRAS,MAP3K11,MAP3K6,HGF,CDKN1A,CCND1, MAP3K3,PRKCB
CD27 signaling inlymphocytes	2.70	0.105	NFKBIA,MAP3K11,MAP3K6,IKBKE, CD27,MAP3K3
B cell receptorsignaling	2.66	0.067	ETS1,NRAS,NFKBIA,MAP3K11,MAP3K6,FCGR2A,PIK3AP1,IKB KE, FCGR2B,MAP3K3,PRKCB
High mobilitygroup box 1(HMGB1)signaling	2.54	0.081	TLR4,VCAM1,NRAS,RND3,RHOB,RHOU,IFNGR1,TNF
Xenobioticmetabolismsignaling	2.48	0.054	ALDH4A1,MGST1,MAP3K11,NRAS,MAP3K6,GSTM5,CHST12, HS6ST1,MGST2,IL1B,ALDH3B1,CHST13,NFE2L2,TNF,MAP3K3, PRKCB
Cholinebiosynthesis	2.39	0.136	PCYT1B,CHPT1,PLD1
Vitamin DReceptor/RXRactivation	2.38	0.086	SERPINB1,SPP1,CAMP,GADD45A,CDKN1A, CEBPA,PRKCB
TREM1 signaling	2.38	0.085	TLR4,LAT2,MPO,IL1B,FCGR2B,TNF
TNFR2 signaling	2.25	0.121	TANK,NFKBIA,IKBKE,TNF
PI-3-kinasesignaling in Blymphocytes	2.20	0.064	TLR4,NRAS,C3,NFKBIA,ATF5,PIK3AP1, IKBKE,FCGR2B,PRKCB

*Top pathways from analysis of RNAs with >1.5-fold change in 2 experiments, with affected genes listed and ordered by –logP values. R values, indicating the proportion of genes in a pathway affected by Cebpa knockdown, are also shown.