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. 2014 Apr 21;9(4):e94663. doi: 10.1371/journal.pone.0094663

Figure 4. A) Histogram showing the iTRAQ ratios of selected proteins related to focal adhesion (ITGA2B, TLN1 and FLNA) and coagulation cascade (FGA, FGB and PLG).

Figure 4

Demographically matched control group was used as the common denominator (i.e. 114) for comparing the three groups of LACI patients. The solid line indicates no change in regulation. The LACI groups with adverse outcome (recurrent vascular event, 116; cognitive decline, 117) had a differential signature in comparison with the LACI group with no adverse outcome (i.e. 115). Up-regulation of proteins related to focal adhesion and coagulation (FGA, FGB) at the baseline is predictive of poor outcome. *Denotes ratios with significant p-value (<0.05). B) Schematic diagram showing the interaction of various ligands of ITGA2B on platelet membrane and the probable involvement down-stream intracellular proteins (e.g. TLN1 and FLNA) in vascular dysfunction that may be responsible for poor prognosis. Aspirin partially blocks the integrin signaling as seen in the flowchart.