Table 4.
Association between vaginal bacterial community state type, menopausal status and signs of vulvovaginal atrophy, adjusted for confounding factorsa
| Community state type | (CST) CST I | CST II or Vb | CST III | CST IVA | CST IVB | ||||
|---|---|---|---|---|---|---|---|---|---|
| Dominant bacterial species | L. crispatus | L. gasseri or L. jensenni | L. iners | Low-lactobacillus | Low-lactobacillus, Atopobium | ||||
| Vulvovaginal atrophyd | OR (95% CrI)c | aOR (95% CrI) | OR (95% CrI) | aOR (95% CrI) | OR (95% CrI) | aOR (95% CrI) | OR (95% CrI) | aOR (95% CrI) | |
| Mild or Moderate | 1 | 0.53 (0.01, 5.08) | 0.32 (0.01, 3.61) | 0.46 (0.05, 2.94) | 0.46 (0.05, 3.01) | 23.58 (3.64, 234.05) | 25.89 (2.98, 406.79) | 3.50 (0.74, 18.82) | 5.24 (0.85, 40.42) |
| None | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Vaginal drynesse | |||||||||
| Mild, Moderate, or Severe | 1 | 1.20 (0.03, 12.86) | 0.96 (0.02, 15.10) | 1.10 (0.10, 17.92) | 1.09 (0.10, 11.12) | 11.15 (1.55, 122.82) | 9.92 (0.98, 117.82) | 3.89 (0.48, 42.05) | 3.71 (0.41, 40.50) |
| None | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
a
Analysis adjusted for sexual activity in prior 6 months, race, marital status, and lifetime number of sexual partners
b
CSTs combined due to data sparseness.
c
Odds ratio (OR) and adjusted odds ratio (aOR) with 95% credible interval (CI).
d
Mild and moderate vulvovaginal atrophy combined due to data sparseness.
e
Mild, moderate and severe vaginal dryness combined due to data sparseness.