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. Author manuscript; available in PMC: 2015 Apr 9.
Published in final edited form as: Oncogene. 2013 Oct 21;33(41):4932–4940. doi: 10.1038/onc.2013.435

Figure 3.

Figure 3

NKG2D effects on tumor latency, incidence and growth in the orthotopic SUM149PT xenotransplant model. (a) Graphic representation of tumor development over time measured in weekly intervals (top numbers) following implantation of SUM149PT–TF and SUM149PT–mock lines shows absence of NKG2D effects on tumor latency and frequency. Dark grey squares indicate presence of measurable tumor mass; light grey squares indicate absence of tumor mass. Left vertical numbers refer to mouse identifications (mID). (b) Graphic representations of SUM149PT–TF and SUM149PT–mock tumor volume averages and standard deviations at the indicated weekly time intervals post inoculation. Data were derived from each eight mice per group corresponding to those in (a) monitored for 7 weeks. Asterisk denotes p<0.05; double asterisk denotes p<0.001. (c) Graphic representation of SUM149PT–TF and SUM149PT–mock tumor volume averages normalized to times of tumor appearance. Data were derived from the same mice studied in (b). Normalization of tumor volumes to times of tumor appearances affects group sizes at each weekly interval as follows: Weeks 1 to 4, SUM149PT–TF (n=8) and SUM149PT–mock (n=8); week 5, SUM149PT–TF (n=7) and SUM149PT–mock (n=5). Asterisk denotes p<0.05. (d) Graphic representations of SUM149PT–TF, SUM149PT–TF–RNAi, and SUM149PT tumor volume averages and standard deviations at the indicated weekly time intervals post inoculation. Data were derived from each six mice per group monitored for at least 9 weeks in experiment denoted run 2 (see text). (e) Graphic representation of SUM149PT–TF, SUM149PT–TF–RNAi, and SUM149PT tumor volume averages normalized to times of tumor appearance. Data were derived from the same mice studied in (d). Normalization of tumor volumes to times of tumor appearances affects group sizes at each weekly interval as follows: Weeks 1 to 4, SUM149PT–TF (n=6), SUM149PT–TF–RNAi (n=6), and SUM149PT (n=6); week 5, SUM149PT–TF (n=6), SUM149PT–TF–RNAi (n=5), and SUM149PT (n=6). (f) Representation of SUM149PT–TF and SUM149PT–TF–scrRNAi tumor volume averages and standard deviations at the indicated weekly time intervals post tumor cell inoculation. Data were derived from each six mice per group monitored for eight weeks.