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Tissue to plasma exposure ratio of paclitaxel for tumor, liver, and spleen following intravenous administration
|
Tissue to plasma ratio |
Formulation |
|
|---|---|---|
| Cremophor EL:ethanol | Nanosuspension | |
| Tumor AUC0-8/plasma AUC0-8 |
0.7 |
8.3 |
| Liver AUC0-8/plasma AUC0-8 |
3.6 |
810.0 |
| Spleen AUC0-8/plasma AUC0-8 | 1.1 | 16.8 |
AUC0-8, area under the concentration-time profile from 0 to 8 h.
