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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Clin Cancer Res. 2014 Feb 13;20(7):1768–1778. doi: 10.1158/1078-0432.CCR-13-2697

Fig. 3.

Fig. 3

Sequence homology of MCPyV-derived CD8 T-cell epitopes within different strains of MCPyV and among other human polyomaviruses. (A) Circle diagram illustrating the variation within the T-cell epitope sequences of LTA from 88 different strains of MCPyV. 17% of the sequences carried a SNP at amino acid position 20, located in both the A2-LTAKLL and B7-LTAAPN epitope causing the indicated changes in the amino acid sequence. (B) Alignment of the MCPyV LTA amino-acid sequence (top) with the corresponding amino-acid sequences from the 10 other known human polyomaviruses, BKPyV, JCPyV, KIPyV, WUPyV, HPyV6, HPyV7, HPyV8, HPyV9, MWPyV and STLPyV. Grey boxes represent the position of the MCPyV-derived A2-, A11-, and B7-restricted epitopes. Amino acids from the other human polyomaviruses that differ from the MCPyV sequence are highlighted in bold. Below, in each epitope the anchor residues are in bold and the auxiliary anchor residues are underlined.