Table 2.
Peptides eliciting CD8 T cell responses in MCC patients and healthy donors.
| Antigen | Peptide sequence |
AA position |
Length | MCC | Healthy Donors |
HLA restriction |
|---|---|---|---|---|---|---|
| Vp1 | SITQIELYL | 51 | 9 | 1/26 | A2 | |
| NLPAYSVARV | 97 | 10 | 1/26 | 1/16 | A2 | |
| NLINSLFSNL | 326 | 9 | 1/26 | A2 | ||
| FLDKFGQEKT | 372 | 9 | 1/26 | A2 | ||
| ALHGLPRYFNV | 301 | 11 | 1/26 | A2 | ||
| LLVKGGVEV | 34 | 9 | 1/26 | A2 | ||
| KPGCCPNVA | 21 | 9 | 1/NA | B7 | ||
| LPAYSVARVSL | 98 | 11 | 1/NA | B7 | ||
| LPRYFNVTLRK | 305 | 11 | 1/NA | B7 | ||
| LPRYFNVTL | 305 | 9 | 1/13 | B7 | ||
| ITIETVLGR | 195 | 9 | 1/16 | A3 | ||
| GLDPQAKAK | 211 | 9 | 1/16 | A3 | ||
| TLRKRWVKN | 312 | 9 | 1/16 | A3 | ||
| SLFSNLMPK | 330 | 9 | 2/16A3 | 2/7A11 | A3/A11 | |
| KMALHGLPR | 299 | 9 | 1/14 | A3 | ||
| TVLGRKMTPK | 199 | 10 | 4/16 | 1/14 | A3 | |
| NSLFSNLMPK | 329 | 10 | 1/16 | A3 | ||
| VTLRKRWVK | 311 | 9 | 1/7 | A11 | ||
| SLINVHYWDMK | 137 | 11 | 1/16A3, 1/7A11* | A3/A11 | ||
| QMWEAISVK | 121 | 9 | 3/16A3, 1/7A11* | A3/A11 | ||
| LQMWEAISVK | 120 | 10 | 1/16A3, 1/7A11* | A3/A11 | ||
| DLQGLVLDY | 174 | 9 | 1/7A11 | A11 | ||
| VLGRKMTPK | 200 | 9 | 1/7A11 | A11 | ||
| LTA | HSQSSSSGY | 137 | 9 | 1/14 | A1 | |
| VIMMELNTL | 50 | 9 | 1/26 | A2 | ||
| SMFDEVDEAPI | 74 | 11 | 2/26 | A2 | ||
| KLLEIAPNC | 15 | 9 | 2/26 | A2 | ||
| ASFTSTPPK | 294 | 9 | 1/16 | A3 | ||
| AAFKRSCLK | 32 | 9 | 1/7 | A11 | ||
| APIYGTTKF | 82 | 9 | 2/NA | B7 | ||
| APNCYGNIPL | 20 | 10 | 1/NA | B7 | ||
| APNCYGNIPLM | 20 | 11 | 1/NA | B7 | ||
| STA | KTLEETDYCLL | 171 | 11 | 1/26 | A2 | |
| TLEETDYCL | 172 | 9 | 1/26 | A2 | ||
| QLRDSKCACI | 113 | 10 | 1/26 | A2 |
Peptides in bold: T cell epitopes where processing and presentation is verified (see fig 3).
MCC and Healthy donor column: Number of times a response was detected/numbers of investigated HLA matched individuals.
*
Detected in the same individual.
NA: Not available. B7 tissue type was not available for the MCC patients; they were all tested for B7 responses.