Table 1.
Results from a randomized-crossover trial of sodium restriction in hypertensive CKD patients
| Baseline | High sodium | Low sodium | |
|---|---|---|---|
| Sodium excretion (mmol/24 hr)# |
127 (80–187) |
168 (146–219) |
75 (58–112)* |
|
Kidney function |
|
|
|
| eGFR# (mL/min) |
32 (23–42) |
39 (23–39) |
30 (17–36)* |
| Serum creatinine# (μmol/L) |
184 (135–244) |
149 (135–230) |
172 (157–276)* |
| Serum urate# (mmol/L) |
0.44 (0.40–0.47) |
0.39 (0.34–0.45) |
0.46 (0.41–0.51)* |
| Protein: Creatinine (24 h urine)# (g/mol creat) |
49 (12–97) |
68 (23–164) |
41 (17–126)* |
| Albumin: Creatinine (24 h urine)# (g/mol creat) |
21 (2–65) |
27 (5–127) |
9 (2–82)* |
|
Volume status |
|
|
|
| Extracellular/Intracellular fluid ratio |
0.86 ± 0.14 |
0.92 ± 0.14 |
0.87 ± 0.13* |
| Overhydration (L)# |
−0.6 (−1.6–1.4) |
0.8 (−1.1–2.6) |
−0.5 (−1.7–0.9)* |
| NT–proBNP (pg/mL)# |
NA |
330 (167–793) |
205 (124–528)* |
|
Inflammatory markers |
|
|
|
| C-reactive protein (mg/L)# |
3.3 (1.6–5.8) |
2.8 (1.5–5.5) |
2.7 (1.0–7.3) |
| Interleukin-6 (pg/mL)# |
NA |
1.9 (1.6–2.8) |
1.9 (1.4–2.8) |
| Interferon-gamma (pg/mL)# |
NA |
0.8 (0.5–1.1) |
1.0 (0.5–1.4) |
| Tumor necrosis factor – alpha (pg/mL)# |
NA |
6.8 (5.8–8.7) |
7.3 (5.3–9.0) |
| Total adiponectin (ng/L) |
8.1 ± 3.5 |
7.8 ± 3.6 |
8.0 ± 3.7 |
| High molecular weight adiponectin (μg/mL) | 5.6 ± 3.1 | 3.9 ± 2.5 | 3.9 ± 2.6 |
Data are presented as mean ± standard deviation, median (interquartile range).
NA Data not avaliable.
*p < 0.05 High vs low sodium #log transformed prior to analysis.