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. Author manuscript; available in PMC: 2014 Apr 22.
Published in final edited form as: Expert Opin Drug Metab Toxicol. 2010 Oct 23;6(12):1477–1491. doi: 10.1517/17425255.2010.523420

Figure 2. Schematic of microdialysis catheter membrane.

Figure 2

Schematic depiction of the probe portion of a microdialysis catheter (not drawn to scale). The semi-permeable membrane at the tip of the probe allows diffusion of fluid (perfusate out and ECF in) along concentration gradients. Perfusate enters the central portion of the probe under a constant flow rate (i.e., 1 μl/min). It then moves to the outer compartment of the probe where it is admixed with the ECF and the solute under investigation (grey drops) is collected in the outlet tubing.

ECF: Extracellular fluid.