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Binding interactions of DHEA and 4-OHPCB 34 with hSULT2A1 in the PAP-bound conformation. DHEA (Panel A) and 4-OHPCB 34 (Panel B) bind at the same site. Key hSULT2A1 residues interacting with the ligands at the active site are shown. Total score of 3.96 based on a consensus score of 3 for binding of DHEA, and total score of 3.63 based on a consensus score of 5 for binding of 4-OHPCB 34 were obtained. (crystal structure: hSULT2A1 in the conformation observed with PAP bound (1EFH)).
