. Author manuscript; available in PMC: 2015 Apr 5.

Published in final edited form as: Chem Biol Interact. 2014 Feb 5;212:56–64. doi: 10.1016/j.cbi.2014.01.018

Table 2.

Dissociation constants for 15 OHPCBs as inhibitors of the sulfation of DHEA catalyzed by hSULT2A1

OHPCB	K_i (µM)^a
4’-OHPCB 3	17 ± 1.5
4’-OHPCB 6	5.4 ± 0.2
4-OHPCB 8	5.0 ± 0.4
4’-OHPCB 9	0.7 ± 0.1
4-OHPCB 11	12 ± 0.9
4’-OHPCB 12	4.0 ± 0.3
4-OHPCB 14	13.5 ± 1.0
4’-OHPCB 25	3.0 ± 0.6
4’-OHPCB 33	3.0 ± 0.2
4-OHPCB 34	0.8 ± 0.1
4-OHPCB 36	3.4 ± 0.8
4’-OHPCB 68	0.6 ± 0.1
6’-OHPCB 35	9.0 ± 0.5
3’,4’-diOHPCB 3	32 ± 2.3
3’,4’-diOHPCB 5	14 ± 0.8

With the exception of 4’-OHPCB 36, values for K_i were calculated using a nonlinear regression fit to a noncompetitive inhibition equation. The K_i for 4’-OHPCB 36 was obtained from a fit of the data to an equation for competitive inhibition.