Table 1.

Patient characteristics. Summary statistics of patient characteristics in the CSSCD cohort, and the PUSH, WALK-PHaSST and C-Data replication cohorts. For each cohort statistics (mean and standard deviate or frequencies) are reported for all patients included in the analysis. The last row reports the frequency and proportion of individuals with gene deletion alpha thalassemia (at least one alpha gene deletion).

	CSSCD (N=841) Mean (StD)	PUSH (N=77) Mean (StD)	Walk-PHaSST (N=181) Mean (StD)	C-Data (N=127) Mean (StD)
Age (years)	17.19(10.69)	12.49 (4.69)	36.35 (12.54)	13–17
Gender (% male)	53.7%	50.6%	51.9%	55.9%
HbF (%)	6.65 (5.50)	9.81 (8.23)	6.07 (5.60)	7.59(5.09)
Hemoglobin (d/mL)	8.42 (1.33)	8.62 (1.25)	8.50 (1.69)	NA
α thalassemia (% yes)	143 (31.4%)	21 (27.2%)	46 (25.4%)	NA