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. Author manuscript; available in PMC: 2014 Sep 6.
Published in final edited form as: Oncogene. 2013 Mar 11;33(10):1316–1324. doi: 10.1038/onc.2013.57

Figure 7.

Figure 7

MP470 inhibition of AXL decreases self-renewal of BCSCs and restores sensitivity to chemotherapy. A, Photomicrograph of mammospheres generated from ANV5 cells treated with varying concentration of MP470 or only DMSO (ANV5). B, Bar graphs showing the mean (± SEM, N=8) number of the mammospheres formed by different treatments described above. C, Chemosensitivity graphs are shown for stable AXL-knockdown and control ANV5 cells were treated with Etoposide. Each bar is the slope of growth tracing as measured by impedance. Note that the change in slope is greater in the AXL-knockdown cells as compared to control ANV5-PLK cells. D, Chemosensitivity graphs of DMSO control or MP470-pretreated (20 µM) ANV5 cells subsequently exposed to Salinomycin. E, Shown are the mean (±SEM, n=6) relative luminescence units (RLU) of Control or MP470-pre-treated ANV5 cells subsequently treated with varying doses of paclitaxel. p-values were derived using one-way ANOVA within treatments. ***p<0.001; ns, not significant. The experiments in this figure were repeated independently at least three times with similar results.