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. 2014 May;141(9):1864–1874. doi: 10.1242/dev.105791

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© 2014. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Conserved actin-associated domains are required for Mena function at the synapse. (A-H) Images of Drosophila 6/7 NMJ expressing wild-type or mutant UAS-EGFP-Mena transgenes using the pan-muscle how^24B-Gal4 driver. Scale bars: 20 μm. Muscle expression of UAS-EGFP-Mena^WT (C), UAS-EGFP-Mena^ΔPRR (D) and UAS-EGFP-EVH2 (H) show significantly disrupted NMJ morphogenesis. (I) Quantification of synaptic boutons and NMJ expansion. Expression of UAS-EGFP-Mena^ΔGAB (E), UAS-EGFP-Mena^ΔFAB (F) and UAS-EGFP-Mena^ΔCC (G) is indistinguishable from wild-type control NMJs. Error bars indicate s.e.m. *P≤0.01, **P≤0.001 relative to how^24B-Gal4/+ animals (two-tailed Student's t-test). n≥17 for all genotypes and parameters.