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. 2014 May;141(9):1864–1874. doi: 10.1242/dev.105791

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© 2014. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 7. — miR-8 mediates SSR elaboration through repression of Ena activity. (A-E) Analysis of electron micrographs of type Ib synaptic boutons at the 6/7 NMJ. (A-D) SSR (pseudocolored red) and presynaptic bouton (pseudocolored yellow). Representative image of a control w¹¹¹⁸ (A) synaptic bouton with surrounding SSR. Both miR-8^Δ/Δ (B) and how^24B-Gal4>UAS-Ena (C) display significant reduction in SSR area relative to control (A). Expression of how^24B-Gal4>UAS-FP₄-mito in a miR-8^Δ/Δ background significantly rescues all synaptic bouton elaboration defects observed in miR-8 homozygous mutants presynaptically (green) and postsynaptically (red, D). Scale bars: 500 nm. SSR thickness and area of w¹¹¹⁸ (n=23), miR-8^Δ/Δ (n=31), how^24B-Gal4>UAS-Ena (n=23) and miR-8^Δ/Δ; how^24B-Gal4>UAS-FP₄-mito (n=21). Error bars indicate s.e.m. ***P≤0.0001, **P≤0.001, relative to w¹¹¹⁸ control (two-tailed Student's t-test).