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. Author manuscript; available in PMC: 2014 Apr 22.
Published in final edited form as: Exp Neurol. 2013 Jan 24;243:57–66. doi: 10.1016/j.expneurol.2013.01.014

Fig. 1.

Fig. 1

Thy1-aSyn mice show an age-related decline in daily and circadian rhythms. Top panels show representative examples of wheel-running activity records from WT (left) and Thy1-aSyn (right) mice. Animals were initially entrained to 12:12 LD, then placed into a skeleton photoperiod (1: 11:1:11 LD). Each horizontal row represents the activity record for a 24-hr day that is then double plotted. Successive days are plotted from top to bottom. Gray shaded area represents darkness. Bottom panels show examples of average waveforms that illustrate the distribution of activity for WT (left) and Thy1-aSyn (right) mice. Besides the striking reduction in the amplitude of activity, the Thy1-aSyn mice exhibited a decrease in precision of the beginning of the nightly activity cycle and an increase in fragmentation of their activity. Data from Kudo et al., 2011b.