Table 2.
List of included single nucleotide polymorphisms (SNPs), and their frequencies (percentages)
| |
Genotype |
|||||
|---|---|---|---|---|---|---|
| Gene | n |
GG |
GA |
AA |
CC |
CA |
| n (%) | n (%) | n (%) | n (%) | n (%) | ||
| ABCC2/MRP2rs8187710 |
954 |
842 (88.3) |
110 (11.5) |
2 (0.2) |
|
|
| ABCG2/BRCPrs2231137 |
955 |
888 (93.0) |
67 (7.0) |
|
|
|
| CYP2B6rs2279343 |
910 |
57 (6.2) |
382 (42.0) |
471 (51.8) |
|
|
| CYP2C8rs72558196 |
960 |
|
|
960 (100) |
|
|
| CYP2C9rs1057910 |
954 |
|
|
853 (89.4) |
3 (0.3) |
98 (10.3) |
| CYP2C19rs4244285 |
946 |
652 (68.9) |
266 (28.1) |
28 (3.0) |
|
|
| CYP2C19rs4986893 |
960 |
960 (100) |
|
|
|
|
| CYP3A4rs2740574 |
955 |
2 (0.2) |
57 (6) |
896 (93.8) |
|
|
| CYP3A4rs55785340 |
957 |
|
|
957 (100) |
|
|
| CYP3A5rs776746 |
959 |
834 (87.0) |
118 (12.3) |
7 (0.7) |
|
|
| DPYDrs1801159 |
960 |
47 (4.9) |
267 (27.8) |
646 (67.3) |
|
|
| DPYDrs3918290 |
949 |
945 (99.6) |
4 (0.4) |
|
|
|
| DPYDrs1801160 |
957 |
853 (89.1) |
96 (10.0) |
8 (0.9) |
|
|
| GSTA1rs3957357 |
938 |
329 (35.1) |
441 (47.0) |
168 (17.9) |
|
|
| GSTP1rs1695 |
959 |
118 (12.3) |
452 (47.1) |
389 (40.6) |
|
|
| MRP1rs1883112 |
956 |
295 (30.9) |
485 (50.7) |
176 (18.4) |
|
|
| MRP1rs7853758 |
952 |
701 (73.6) |
231 (24.3) |
20 (2.1) |
|
|
| MTHFRrs1801131 |
951 |
|
|
446 (46.9) |
92 (9.7) |
413 (43.4) |
| UGT2B7rs12233719 |
949 |
949 (100) |
|
|
|
|
| UGT2B7rs7662029 |
955 |
210 (22.0) |
473 (49.5) |
272 (28.5) |
|
|
| XPD/ERCC2rs1799793 |
954 |
412 (43.2) |
429 (45.0) |
113 (11.8) |
|
|
| XRCC1rs25489 |
954 |
875 (91.7) |
77 (8.1) |
2 (0.2) |
|
|
| XRCC3rs861534 |
949 |
357 (37.6) |
441 (46.5) |
151 (15.9) |
|
|
|
Gene |
n |
TT |
CC |
CT |
AA |
TA |
|
n (%) |
n (%) |
n (%) |
n (%) |
n (%) |
||
| ABCC2/MRP2rs17222723 |
951 |
843 (88.6) |
|
|
2 (0.2) |
106 (11.2) |
| ABCC2/MRP2rs2804402 |
935 |
297 (31.8) |
185 (19.8) |
453 (48.4) |
|
|
| CYP2B6rs8192709 |
927 |
|
846 (91.3) |
87 (8.7) |
|
|
| CYP2C8rs10509681 |
960 |
740 (77.1) |
12 (1.2) |
208 (21.7) |
|
|
| CYP2C9rs1799853 |
957 |
15 (1.6) |
712 (74.4) |
230 (24) |
|
|
| CYP3A4rs4986910 |
959 |
938 (97.8) |
|
21 (2.2) |
|
|
| DPYDrs1801265 |
960 |
635 (66.1) |
46 (4.8) |
279 (29.1) |
|
|
| FGFR4rs351855 |
954 |
88 (9.2) |
461 (48.3) |
405 (42.5) |
|
|
| GSTP1rs1138272 |
952 |
6 (0.6) |
778 (81.7) |
168 (17.7) |
|
|
| MDRI/ABCB1rs1045642 |
914 |
265 (29.0) |
208 (22.8) |
441 (48.2) |
|
|
| MRP1rs13058338 |
949 |
482 (50.8) |
|
|
67 (7.1) |
400 (42.1) |
| MRP1rs246221 |
956 |
462 (48.3) |
71 (7.4) |
423 (44.3) |
|
|
| MRP1rs3743527 |
930 |
13 (1.4) |
562 (60.4) |
355 (38.2) |
|
|
| MRP1rs4673 |
954 |
115 (12.0) |
406 (42.6) |
433 (45.4) |
|
|
| MTHFRrs1801133 |
959 |
121 (12.6) |
401 (41.8) |
437 (45.6) |
|
|
| NQO1rs1800566 |
958 |
35 (3.6) |
605 (63.2) |
318 (33.2) |
|
|
| UGT2B7rs7439366 |
955 |
272 (28.5) |
210 (22.0) |
473 (49.5) |
|
|
| UGT2B7rs7668282 |
954 |
940 (98.5) |
1 (0.1) |
13 (1.4) |
|
|
|
Gene |
n |
GG |
GT |
TT |
CC |
CG |
|
n (%) |
n (%) |
n (%) |
n (%) |
n (%) |
||
| ALDH3A1rs2228100 |
934 |
67 (7.2) |
|
|
554 (59.3) |
313 (33.5) |
| CYP2B6rs3745274 |
954 |
535 (56.1) |
365 (38.2) |
54 (5.7) |
|
|
| GPX4rs757229 |
940 |
263 (28.0) |
|
|
212 (22.5) |
465 (49.5) |
| MRP1rs4148350 |
957 |
847 (88.5) |
105 (11.0) |
5 (0.5) |
|
|
| MRP1rs45511401 |
960 |
847 (88.2) |
109 (11.4) |
4 (0.4) |
|
|
| UGT2B7rs3924194 |
954 |
19 (2.0%) |
|
|
712 (74.6) |
223 (23.4) |
| XPD/ERCC2rs13181 |
951 |
116 (12.2) |
449 (47.2) |
386 (40.6) |
|
|
|
Gene |
n |
GG |
GT |
TT |
GA |
TA |
|
n (%) |
n (%) |
n (%) |
n (%) |
n (%) |
||
| MDRI/ABCB1rs2032582 |
948 |
283 (29.9) |
445 (46.9) |
185 (19.5) |
23 (2.4) |
12 (1.3) |
| TYMSrs11280056 | 918 | AAGTTA 442 (48.2) |
AAGTTA.DEL 394 (42.9) |
DEL 82 (8.9) |
||