. 2014 Feb 1;76:11–16. doi: 10.1016/j.curtheres.2013.11.001

Table II.

Levels of biochemical markers in the serum of experimental animals, by dose of thymoquinone.

Marker	S	C	T100	T200	T400	P
Marker	Mean (SD)					P
PON	30.67 (4.49)	25.99 (5.68)	78.63 (1.80)^*^,^†	80.15 (3.48)^*^,^†	112.76 (17.98)^*^,^†,‡	<0.01
TAS	0.44 (0.06)	0.04 (0.03)^*	2.25 (0.46)^*^,^†	2.88 (0.36)^*^,^†	2.10 (0.42)^*^,^†	<0.01
TOS	22.77 (4.86)	34.27 (1.29)	1.31 (1.02)^*^,^†	3.41 (1.61)^*^,^†,‡	1.94 (1.30)^*^,^†	<0.01
IL-1β	1.22 (0.53)	2.48 (1.17)^*	1.76 (1.38)^*^,^†	1.82 (1.41)^*	1.91 (1.43)^*	<0.01
TNF-α	0.23 (0.41)	3.57 (3.62)^*	0.89 (1.45)^*^,^†	0.45 (0.83)^†	0.25 (0.47)^‡	<0.01
NO	0.17 (0.04)	0.24 (0.06)^*	0.16 (0.25)^†	0.19 (0.08)^†,‡	0.19 (0.06)^*^,^†,‡	<0.01
MDA	20.37 (4.54)	37.20 (8.92)^*	19.40 (2.49)^†	22.20 (2.55)^†	20.89 (2.63)^†	<0.01

C = control group; IL-1β = interleukin-1 β; MDA = malondialdehyde; NO = nitric oxide; PON = serum paraoxonase; S = sham group; T100 = thymoquinone 100 mg/kg/PO group; T200 = thymoquinone 200 mg/kg/PO group; T400 = thymoquinone 400 mg/kg/PO group; TAS = total antioxidant status; TNF-α = tumor necrosis factor α; TOS = total oxidant status.

^⁎

Different from S group (P < 0.01).

^†

Different from C group (P < 0.01).

^‡

Different from T100 group (P<0.01).