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. 2014 Apr 12;63(5):1712–1724. doi: 10.2337/db13-1141

Figure 4.

Figure 4

Lymphocytic infiltration of the islets at termination by donor. Examples of lymphocytic infiltration of the pancreatic islets at termination in mice injected with PBMC (n = 56) or CD4+ T-cell lines (n = 108). Each data point represents one individual islet. A breakdown of the islet scores resulting from CD4+ line injections for each donor is shown. ●, IGRP23-pulsed CD4 T-cell lines; ■, IGRP247-pulsed CD4 T-cell lines; ▲, PPI88S-pulsed CD4 T-cell lines; ▼, IGRP23/IGRP247 combination–pulsed CD4 T-cell lines. Statistical significance was determined using nonparametric ANOVA (T1D001 overall P = 0.0142, T1D029 overall P = 0.002, T1D584 overall P = 0.0019, HD004 overall P = 0.0048). *P < 0.05; **P < 0.01.