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. 2014 Apr 12;63(5):1672–1684. doi: 10.2337/db13-1226

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© 2014 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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Postnatal neutralizing IL-4 treatment prevents fasting hyperglycemia and loss of β-cell mass in adulthood. Glucose homeostasis and β-cell mass was measured in 6–10-month-old adult animals: (A) fasting blood glucose (n = 8 animals/treatment group); (B) fasting C-peptide levels (picomolar; n = 8 animals/treatment group; (C) islet mass (mg per total pancreas; n = 4 animals/treatment group). Values are ± SEM. *, significant difference at P < 0.05 versus CV; †, significant difference at P < 0.05 versus IV; white circles, CV; black circles, IV; white squares, CIL4; black squares, IIL4; white bars, CV; gray bars, IV; white bars with hatch marks, CIL4; gray bars with hatch marks, IIL4.