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. 2014 Apr 12;63(5):1612–1623. doi: 10.2337/db13-0707

Figure 3.

Figure 3

Glucose and insulin tolerance test. Mice were injected with 40 mg/kg/day tamoxifen in 100 μL peanut oil for 5 consecutive days, and underwent glucose and insulin tolerance tests 14–22 days later. Results are shown for blood glucose levels at different times after intraperitoneal glucose injection (A), the AUC for blood glucose during intraperitoneal glucose tolerance test (IPGTT) (B), insulin levels at different times after intraperitoneal glucose injection (C), and the AUC for insulin levels (D). A–D: Mice were fasted overnight. E: Blood glucose levels at different times after insulin injection into KMA1ko and WT mice. Overnight fasting blood glucose and plasma insulin were used to assess HOMA-IR (F) or HOMA-B (G). Male and female mice 6 to 8 weeks of age were used. Data are expressed as means ± SE. *P < 0.05 and **P < 0.01 with KMA1ko mice vs. WT; N.S., not significant; n = 7–10 mice per group.