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. 2014 Apr 12;63(5):1612–1623. doi: 10.2337/db13-0707

Figure 4.

Figure 4

Islet morphology and apoptosis and insulin processing. Mice were injected with 40 mg/kg/day tamoxifen in 100 μL peanut oil for 5 consecutive days, and their pancreata were examined 30 days later. A: Hematoxylin and eosin (H & E) stained sections of islets from KMA1ko and WT mice show normal morphology. B: TUNEL staining shows no difference in the frequency of apoptotic cells in the islets of KMA1ko and WT mice (n = 3 mice per group). At 14 to 22 days after the last tamoxifen injection, blood was collected to determine the fasting levels of plasma proinsulin, insulin, and C-peptide by ELISA. C: Ratio of proinsulin to insulin. D: Ratio of proinsulin to C-peptide. N.S., not significant (n = 10 mice per group).