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. 2014 Apr 12;63(5):1612–1623. doi: 10.2337/db13-0707

Figure 6.

Figure 6

KMA1ko in pancreatic β-cells results in defective glucose-induced insulin secretion but normal calcium influx. Mice were injected with 40 mg/kg/day tamoxifen in 100 μL peanut oil for 5 consecutive days. Pancreatic islets isolated on day 7 from WT, KMA1het, and KMA1ko mice were cultured overnight and then preincubated with 2 mmol/L glucose for 5 min and stimulated with 14 mmol/L glucose (A and B), 30 mmol/L KCl for 60 min (C and D), 10 μmol/L carbachol (E and F), or 150 μmol/L exendin-4 (G and H) for 45 min. The insulin secretion (A, C, E, and G) and calcium influx (B, D, F, and H) were measured. Percentage changes in the mean value from the initial levels are expressed. A representative figure from 3 mice is shown.