Figure 1.

The plasma level of H₂S and CSE activity in wound skin tissue was decreased in diabetic mice, which was reversed by it donors. A: Baseline of plasma H₂S level in db/+ and db/db mice (n = 5 each group). *P < 0.05 vs. db/+. B: Plasma H₂S level at day 8 after wound establishment and H₂S donor or PAG treatment (n = 5 in each group). *P < 0.01 vs. db/+ control; #P < 0.01 vs. db/db control. C: Plasma H₂S concentrations at day 16 after wound creation and H₂S donor or PAG treatment (n = 5 each group). *P < 0.05 vs. db/+ control; #P < 0.05 vs. db/db control. D: Baseline of the activity of H₂S synthase CSE in the skin tissue of db/+ and db/db mice (n = 5 in each group). *P < 0.05 vs. db/+. E: There was less CSE activity in the skin tissue of db/db mice than in db/+ mice (n = 5 in each group). *P < 0.01 vs. db/+ control.