. Author manuscript; available in PMC: 2014 Jul 31.

Published in final edited form as: Nat Rev Drug Discov. 2014 Feb;13(2):140–156. doi: 10.1038/nrd4204

Table 1.

Emerging Targets within the PI3K signaling network

Target	Upstream activators	Effectors/Substrates	Tool Compounds (Refs.)
eIF4E	mTORC1, MNK	Cap-dependent translation	4EGI-I¹²⁹ 4ei-1²¹³
S6K	mTORC1, PDK1	S6, PDCD4, eIF4B, eEF2K, SKAR	PF-4608671¹³² DG2¹³¹ LYS6K2¹³⁰
MNK	ERK	eIF4E	CGP57380²¹⁴ AST 487²¹⁵ Cercosporamide²¹⁶
PIM	Growth factor- mediated increase in transcription	eIF4B, 4EBP1, BAD, p27	SMI-4a²¹⁷ ETP-45299²¹⁸ SGI-1776²¹⁹ Pimi-14J²²⁰ K00135²²¹