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. Author manuscript; available in PMC: 2014 Apr 22.
Published in final edited form as: Open Inflamm J. 2011 Oct 7;4:49–60. doi: 10.2174/1875041901104010049

Table 1.

Major heat shock protein families

NAME SIZE (KDA) LOCALIZATION BACTERIAL HOMOLOG SOME KNOWN AND POSSIBLE FUNCTIONS
Ubiquitin 8 Cytosol/nucleus — Nonlysosomal degradation pathways
HSP 27 (HSPB1) 27 Cytosol/nucleus — Regulator of actin cytoskeleton; molecular chaperone; cytoprotection
Heme oxygenase 32 Bound to ER, extends to cytoplasm — Degradation of heme to bilirubin; resistance to oxidant stress
HSP 47 47 ER — Collagen chaperone
HSP 60 (HSPD) 60 Mitochondria Gro EL Molecular chaperone
HSP 70 (HSPA) 72 Cytosol/nucleus Dna K Highly stress inducible; involved in cytoprotection against diverse agents
73 Cytosol/nucleus — Constitutively expressed chaperone
HSP 90 (HSPC) 90 Cytosol/nucleus htpG Regulation of steroid hormone activity
HSP 110 110 Nucleolus/cytosol Clp family Protects nucleoli from stress