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“Leaderless” proteins involved in the host immune response.
| PROTEIN | EXTRACELLULAR FUNCTION | INTRACELLULAR FUNCTION |
|---|---|---|
| IL-1α | Pro-inflammatory cytokine | Activator of transcription |
| IL-1β | Pro-inflammatory cytokine | - |
| IL-18 | Pro-inflammatory cytokine | - |
| Caspase I (ICE) | ? | IL-1/IL-18 converting enzyme |
| HMGB1 | Pro-inflammatory cytokine | Chromatin component |
| IL-16 | Pro-inflammatory cytokine | - |
| MIF | Pro-inflammatory cytokine | Transcription factor modulator |
