Figure 4.

Inhibition of MyD88 homodimerization reduces STBM-induced pro-inflammatory response. Primary monocytes were pre-treated with 1 μM MyD88 inhibitor peptide for 24 h prior incubation with the indicated concentrations of LPS or STBM-NP during 12 h. The concentrations of IL-8 (A) and IL-6 (B) secreted by the cells were quantified by ELISA and are presented as a percentage of the amounts secreted in absence of pre-treatment with the inhibitor. Data represent mean ± SEM of three monocyte co-culture experiments with STBM-NP prepared from four placentas. *p < 0.05; **p < 0.01. LPS was used as a positive control.