Table 1.
TCR-transgenic models employed in studies of anti-tumor CD4+ T cell responses.
| TCR-Tg model | Antigen | Classification of antigen | Antigen location | MHC II restriction | Peptide | Reference |
|---|---|---|---|---|---|---|
| 4B2A1 (λ2315) | Light chain idiotype (Id) of mouse M315 myeloma protein | Mutated tumor-specific antigen | Secreted, plasma membrane (52, 53) | I–Ed | aa91–101 | (46) |
| 7A6 (Trp1) | Mouse tyrosinase-related protein 1 | Melanocyte-specific differentiation antigen | Secreted, melanosome membrane (54) | I–Ab | aa113–125 | (35) |
| Marilyn (H–Y) | Minor histocompatibility antigen (Dby) | Tissue antigen | Secreted, cell membrane (55, 56) | I–Ab | aa608–622 | (47) |
| T2.5-5 (HA) | Influenza PR8 hemagglutinin | Viral antigen | Varying (construct dependent)1 | I–Ad | aa126–138 | (48) |
| 14.3.d (HA) | Influenza PR8 hemagglutinin | Viral antigen | Varying (construct dependent)1 | I–Ed | aa110–120 | (49) |
| DO11.10 (OVA) | Chicken ovalbumin | Xenogeneic model antigen | Varying (construct dependent)2 | I–Ad | aa323–339 | (50) |
| OT-II (OVA) | Chicken ovalbumin | Xenogeneic model antigen | Varying (construct dependent)2 | I–Ab | aa323–339 | (51) |
1Varyingly expressed by fusion to other proteins, which control cellular distribution. The viral protein, as such, localizes to the cell surface (57).
2Varyingly expressed as full-length cDNA [containing signal sequence for secretion (58)] or fused to other proteins, which control cellular distribution.