Table 2.
Neuromorphological analyses (mean ± s.e.m.) of GFP-labeled pyramidal neurons in the hippocampi of male and female TMc-Nrg1+/− (Nrg1+/−) mice and their wild-type (WT) littermate controls.
| Male | Female | ||||
|---|---|---|---|---|---|
| WT | Nrg1+/− | WT | Nrg1+/− | ||
| Soma size (μm2) | 92.090 ± 4.974 | 86.850 ± 5.725 | 86.270 ± 4.278 | 80.190 ± 6.040 | |
| Distance to apical bifurcation (μm) | 241.100 ± 55.430 | 265.200 ± 66.730 | 257.100 ± 57.750 | 249.200 ± 65.130 | |
| Number of branches of apical branches | 19.000 ± 2.781 | 18.170 ± 1.249 | 19.880 ± 2.356 | 19.500 ± 1.268 | |
| Number of apical tips | 20.000 ± 2.781 | 18.830 ± 1.138 | 20.630 ± 2.412 | 20.380 ± 1.322 | |
| Total length of the apical tuft (μm) | 3009.000 ± 397.700 | 2621.000 ± 465.900 | 2973.000 ± 370.100 | 2593.000 ± 348.000 | |
| Apical dendritic field area (ADFA) (× 1000 μm2) | 11.100 ± 1.644 | 9.512 ± 2.588 | 10.850 ± 1.493 | 9.532 ± 1.980 | |
| Branch angle of primary apical dendrites (°) | 49.270 ± 4.899 | 68.800 ± 13.010 | 69.650 ± 11.360 | 48.420 ± 7.560 | |
| Number of primary basal dendrites | 3.444 ± 0.242 | 3.900 ± 0.315 | 3.286 ± 0.360 | 3.400 ± 0.221 | |
| The total length of primary basal dendrites (μm) | 79.310 ± 16.820 | 87.610 ± 13.460 | 95.000 ± 30.090 | 69.120 ± 13.810 | |
| Number of branches of basal branches | 20.110 ± 1.989 | 19.400 ± 0.957 | 22.430 ± 1.757 | 21.900 ± 1.980 | |
| Number of basal tips | 22.780 ± 1.722 | 23.000 ± 1.000 | 25.000 ± 1.464 | 24.900 ± 1.894 | |
| The total length of basal dendrites (μm) | 3301.000 ± 293.600 | 3001.000 ± 294.600 | 3590.000 ± 317.500 | 3179.000 ± 429.300 | |
| Basal dendritic field area (BDFA) (× 1000 μm2) | 10.230 ± 1.309 | 8.047 ± 1.077 | 10.690 ± 1.284 | 10.720 ± 1.893 | |
| Sholl analysis of basal dendritic complexity | |||||
| Distance to soma (μm) | 10 | 0.444 ± 0.342 | 1.900 ± 0.795 | 0.429 ± 0.578 | 1.300 ± 0.297 |
| 20 | 4.222 ± 0.946 | 4.800 ± 0.712 | 3.571 ± 0.563 | 4.500 ± 0.429 | |
| 30 | 5.333 ± 1.108 | 7.100 ± 1.016 | 5.429 ± 0.674 | 7.100 ± 0.841 | |
| 40 | 7.333 ± 1.308 | 9.900 ± 1.394 | 10.140 ± 0.702 | 9.600 ± 0.829 | |
| 50 | 10.110 ± 0.955 | 12.400 ± 1.376 | 12.290 ± 0.605 | 11.900 ± 0.680 | |
| 60 | 12.000 ± 1.065 | 13.200 ± 1.083 | 13.570 ± 0.359 | 13.200 ± 0.841 | |
| 70 | 13.110 ± 0.872 | 14.500 ± 0.860 | 15.860 ± 0.716 | 14.300 ± 0.857 | |
| 80 | 14.110 ± 1.138 | 15.800 ± 0.554 | 17.000 ± 1.024 | 14.600 ± 0.951 | |
| 90 | 15.000 ± 1.065 | 16.400 ± 0.806 | 16.570 ± 1.016 | 15.100 ± 0.896 | |
| 100 | 14.780 ± 1.265 | 15.800 ± 0.827 | 16.570 ± 1.083 | 15.200 ± 1.088 | |
| >100 | 9.127 ± 0.632 | 8.756 ± 0.725 | 9.108 ± 1.076 | 8.335 ± 0.509 | |