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. 2014 Apr 14;5:55. doi: 10.3389/fendo.2014.00055

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Copyright © 2014 Kimura.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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p63 expression in UBB and SCN of thyroid. (A–C) Immunofluorescence of E13.5 UBB of wild-type mouse embryos for NKX2-1 (A) and p63 immunohistochemistry (B), and merged image (C). Majority of cells express NKX2-1 while a few cells express p63, both being without overlap. (D,E) SCN from E18.5 Nkx2-1-null embryos for H&E (D) and p63 immunohistochemistry (E). p63 is expressed in the stem/basal cell patterns. (F,G) SCN from E18.5 Nkx2-1; p63-double null embryos for H&E (F) and p63 immunohistochemistry (G). Note that the monolayer of p63-negative cells remain in SCN from Nkx2-1; p63-double null embryos. Arrows indicate ciliated cells observed in the cystic structure.