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Synthesis and metabolism of AcSDKP. Tβ4, a G-actin binding peptide, is cleaved by POP, and subsequently its N-terminal tetrapeptide, AcSDKP, is synthesized. AcSDKP is hydrolyzed and degraded by ACE. ACE-I may suppress miR-324-3p, which may inhibit protein expression of POP. Therefore, the mechanisms underlying the increased levels of AcSDKP by ACE-I may include both the suppression of degradation pathway and the induction of synthesis pathway of AcSDKP.
