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. Author manuscript; available in PMC: 2015 Jan 31.
Published in final edited form as: Circ Res. 2014 Jan 31;114(3):549–564. doi: 10.1161/CIRCRESAHA.114.302022

Figure 5. The role of mTORC1 in ischemia-reperfusion.

Figure 5

mTORC1 inhibition is protective during ischemia through the upregulation of adaptive mechanisms. On the other hand, mTOR is reactivated during reperfusion and takes part in the regulation of physiological processes. The pharmacological modulators of mTOR and the animal models with genetic modifications of the components of the mTOR signaling pathway that have been used in the studies focused on the role of mTOR in ischemia-reperfusion are displayed.

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