Table.
Studies of Sleep Disruption in Inflammatory Bowel Disease
| Author (Year) | Study Population(s) | Sleep Measurement(s) | Main Findings |
|---|---|---|---|
| Zimmerman (2003)17 | Healthy control IBS Inactive IBD | MSI | Increased subjective sleep complaints (IBD/IBS) vs healthy controls |
| Nachmias et al (2006)19 (pediatric) | Inactive IBD | Mini-sleep questionnaire | Moderate to severe sleep disturbances, early morning fatigue |
| Keefer et al(2006)15 | Healthy control IBS Inactive IBD | PSQI PSG | Increased subjective sleep complaints (IBD/IBS) vs healthy controls Sleep disturbances affect quality of life |
| Ranjbaran et al (2007)10 | Healthy control IBS Inactive IBD | PSQI | Poor sleep quality and effect on quality of life in patients with IBD |
| Burgess et al (2010)88 | Inactive IBD | Actigraphy | Decreased sleep efficiency |
| Pirinen et al (2010)16 (pediatric) | Inactive IBD Active IBD | Multiple questionnaires | Severe IBD symptoms associated with sleep disturbance |
| Graff et al(2011)14 | Inactive IBD Active IBD | Multidimensional Fatigue Inventory PSQI ESS | Active disease increased subjective sleep complaints |
| Ali et al(2013)91 | Inactive IBD Active IBD | PSQI | Sleep impairment predictive for subclinical inflammation |
| Graffetal(2013)89 | Inactive IBD Active IBD | Multidimensional Fatigue Inventory PSQI | Poor sleep quality independently associated with increased fatigue |
| Benhayon et al(2013)90 (pediatric) | Inactive/active CD | PSQI | Poor sleep quality in pediatric depressed CD patients Increased PSQI scores associated with disease activity |
| Ananthakrishnan et al (2013)13 | Inactive IBD Active IBD | PROMIS online survey | Sleep impairment associated with disease activity 2-fold increase in active disease at 6 months (CD) |
| Ali et al(2013)29 | Inactive IBD Active IBD | PSQI | Sleep impairment associated with disease activity 3-fold increase in active disease at 6 months (IBD) |
CD, Crohn’s disease; ESS, Epworth Sleepiness Scale; IBD, inflammatory bowel disease; IBS, irritable bowel syndrome; MSI, multisystem inventory; PROMIS, Patient Reported Outcomes Measurement Information System; PSG, nocturnal polysomnography; PSQI, Pittsburgh Sleep Quality Index.