FIG. 4.

IDO activity during the primary CD8+ T cell response to influenza modifies immunodominance in influenza challenged mice. BAL cells from 1MT and control treated groups challenged with PR8 were stained for CD8+ expression and specificity against influenza NP, PA, or PB1 epitopes. Contour plots indicated populations from cells were initially gated for CD8+ expression (top histogram). Percentages in the contour plots (middle panel) and bar graphs (bottom panel) indicate the average frequency (n=3) of CD8+ T cells that are specific for the indicated epitopes±SEM at day 5 or 7 post-challenge.