Table 1.
Effector T Cell Response to Heterologous Influenza Challenge
| Effector CD4+ T cell number±SEM (x1000) | ||||
|---|---|---|---|---|
| Day post challenge | 1MT BAL | Control BAL | 1MT MLN | Control MLN |
| 0 | 1±0 | 2±0 | 151±4 | 169±17 |
| 1 | 5±1 | 4±1 | 169±25 | 181±45 |
| 3 | 11±4 | 9±5 | 263±103 | 208±44 |
| 5 | 73±12 | 48±20 | 602±166 | 496±0 |
| 7 | 50±6 | 84±41 | 486±88 | 473±99 |
| 9 | 32±5 | 33±7 | 354±115 | 287±30 |
| Effector CD8+ T cell number±SEM (x1000) | ||||
|---|---|---|---|---|
| Day post challenge | 1MT BAL | Control BAL | 1MT MLN | Control MLN |
| 0 | 3±1 | 8±2 | 23±1 | 21±4 |
| 1 | 13±3 | 11±3 | 26±3 | 23±1 |
| 3 | 12±3 | 8±3 | 46±17 | 42±9 |
| 5 | 289±120 | 177±69 | 411±82 | 370±0 |
| 7 | 383±72 | 480±223 | 339±85 | 386±81 |
| 9 | 346±51 | 363±51 | 308±83 | 242±53 |
X31 primed mice treated with 1MT or vehicle control were challenged with PR8 28 days later. Number of effector (CD44hi CD62Llo) CD4+/CD8+ T cells presenet in airways (BAL) and MLN at day 0 (before challenge) through day 9 post challenge. Numbers are average cell numbers±SEM. Data are representative of three independent experiments.