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. 2014 Feb 15;9:e201402002. doi: 10.5936/csbj.201402002

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© Itoh et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly cited.

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(A) View of the three hydrophobic pockets in the LSD1 catalytic core. Each pocket is drawn as a green sphere. Pocket 1 is formed by Phe 382, Leu 386, Leu 536, Phe 538, Ala 539, Trp 552, and Phe 692. Pocket 2 is formed by Val 333, Ile 356, Leu 677, Leu 693, and Trp 695. Pocket 3 is formed by Phe 560, Tyr 807, Pro 808, Ala 809, Thr 810 (methyl group), and His 812. (B) Schematic diagram of Figure 1A.